|
|
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 <=> H+ + 4,5-9,10-diseco-3-hydroxy-5,9,17-tri-oxoandrosta-1(10),2-diene-4-oic_acid
|
1.13.11.25
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase
|
–
|
| |
BRENDA:
BR40480
KEGG:
R04597
MetaCyc:
1.13.11.25-RXN
SABIO-RK:
4266
|
|
|
|
testosterone + NADP+ <=> 4-androstene-3,17-dione + NADPH + H+
|
1.1.1.146
11beta-hydroxysteroid dehydrogenase
1.1.1.148
estradiol 17alpha-dehydrogenase
1.1.1.184
carbonyl reductase (NADPH)
1.1.1.2
alcohol dehydrogenase (NADP+)
1.1.1.209
3(or 17)alpha-hydroxysteroid dehydrogenase
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.239
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.62
17beta-estradiol 17-dehydrogenase
1.1.1.64
testosterone 17beta-dehydrogenase (NADP+)
|
–
–
–
–
–
–
–
–
–
–
–
|
| |
BRENDA:
BR29315;
BS438469
KEGG:
R01838
MetaCyc:
1.1.1.51-RXN;
1.1.1.64-RXN
SABIO-RK:
1917
|
|
|
|
cholesterol + NAD+ <=> cholest-4-en-3-one + NADH + H+
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
5.3.3.1
steroid Delta-isomerase
|
–
–
|
| |
KEGG:
R09920
|
|
|
|
5-androstene-3,17-dione <=> 4-androstene-3,17-dione
|
2.5.1.18
glutathione transferase
5.3.3.1
steroid Delta-isomerase
|
–
–
|
| |
BRENDA:
BS1076
KEGG:
R09955
MetaCyc:
RXN66-362
SABIO-RK:
7930
|
|
|
|
3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA <=> 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate
|
6.2.1.41
3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate---CoA ligase
|
–
|
| |
BRENDA:
BR51067
KEGG:
R10769
MetaCyc:
RXN-12746
|
|
|
|
9alpha-hydroxy-1,4-androstadiene_3,17-dione <=> 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione
|
0.0.0.0
|
–
|
| |
BRENDA:
BR52868
KEGG:
R09885
MetaCyc:
RXN-12715
|
|
|
|
4,5-9,10-diseco-3-hydroxy-5,9,17-tri-oxoandrosta-1(10),2-diene-4-oic_acid + H2O <=> 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H+
|
3.7.1.17
4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase
|
–
|
| |
BRENDA:
BR49990
KEGG:
R09883
MetaCyc:
RXN-12718
|
|
|
|
cholest-4-en-3-one + reduced_ferredoxin_[iron-sulfur]_cluster + H+ + O2 <=> (25S)-3-oxocholest-4-en-26-oate + oxidized_ferredoxin + H2O
|
1.14.15.29
cholest-4-en-3-one 26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming]
|
–
|
| |
BRENDA:
BR51666
KEGG:
R11357
MetaCyc:
RXN-17644
|
|
|
|
Delta4-Dafachronic_acid <=> 4-androstene-3,17-dione
|
not assigned
|
–
|
| |
KEGG:
R09919
|
|
|
|
cholest-4-en-3-one + 6 [2Fe-2S]-center + 3 O2 <=> (25R)-3-oxocholest-4-en-26-oate + 6 [2Fe-2S]-center + 4 H2O
|
1.14.15.28
cholest-4-en-3-one 26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming]
|
–
|
| |
BRENDA:
BR51696
KEGG:
R11361
|
|
|
|
epiandrosterone + NAD+ <=> 5alpha-androstane-3,17-dione + NADH
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
1.1.1.210
3beta(or 20alpha)-hydroxysteroid dehydrogenase
1.1.1.239
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
|
–
–
–
–
–
–
|
| |
BRENDA:
BS188512;
BS257033
KEGG:
R09956
SABIO-RK:
13781;
14581
|
|
|
|
O2 + cholesterol <=> cholest-4-en-3-one + H2O2
|
1.1.3.6
cholesterol oxidase
|
–
|
| |
BRENDA:
BS188843
KEGG:
R01459
MetaCyc:
CHOLESTEROL-OXIDASE-RXN
|
|
|
|
5alpha-androstane-3,17-dione + acceptor <=> 4-androstene-3,17-dione + reduced_acceptor
|
1.3.99.5
3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)
|
–
|
| |
KEGG:
R01834
MetaCyc:
RXN-12124
|
|
|
|
testosterone + NAD+ <=> 4-androstene-3,17-dione + NADH + H+
|
1.1.1.112
indanol dehydrogenase
1.1.1.210
3beta(or 20alpha)-hydroxysteroid dehydrogenase
1.1.1.239
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.62
17beta-estradiol 17-dehydrogenase
1.1.1.64
testosterone 17beta-dehydrogenase (NADP+)
|
–
–
–
–
–
–
–
|
| |
BRENDA:
BR29275
KEGG:
R01836
MetaCyc:
1.1.1.51-RXN_WOP;
TESTOSTERONE-17-BETA-DEHYDROGENASE-RXN
SABIO-RK:
1915
|
|
|
|
1,4-androstadiene-3,17-dione + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> 9alpha-hydroxy-1,4-androstadiene_3,17-dione + oxidized_ferredoxin + H2O
|
1.14.15.30
3-ketosteroid 9alpha-monooxygenase
|
–
|
| |
BRENDA:
BR49974
KEGG:
R09860
MetaCyc:
RXN-12691
|
|
|
|
4-androstene-3,17-dione + acceptor <=> 1,4-androstadiene-3,17-dione + reduced_acceptor
|
1.3.99.4
3-oxosteroid 1-dehydrogenase
|
–
|
| |
BRENDA:
BS258852
KEGG:
R09884
MetaCyc:
RXN-12714
|
|
|
|
dehydroepiandrosterone + NAD+ <=> 5-androstene-3,17-dione + NADH + H+
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
|
–
–
|
| |
BRENDA:
BS257032
KEGG:
R09957
MetaCyc:
RXN66-342
SABIO-RK:
7900
|
|
|
|
3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione + O2 + FMNH2 <=> H+ + 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + H2O + FMN
|
1.14.14.12
3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase
|
–
|
| |
BRENDA:
BR49866
KEGG:
R09819
MetaCyc:
RXN-12717
|
|
